Wright Lab University of Iowa
Research

Focus areas of the Wright Lab

The lab is organized around three interconnected lines of inquiry that together aim to map the molecular logic of cellular signaling in disease.

1. Proximity interaction networks

Constructing proximity interaction networks for key regulators of cellular proliferation, cell death, and cellular differentiation.

Protein neighborhood — a central highlighted protein with proximal partners shown as a network of connected dots

Full description coming soon.

2. Novel proximity enzymes

Developing novel proximity-labeling enzymes to capture post-translational modifications in complex biological matrices.

Cartographer's toolkit — a surveying instrument over a molecular landscape, representing different proximity-labeling enzymes

Full description coming soon.

3. Reagents & methods for cell biology

Optimizing cell biology reagents and methods to interrogate the molecular function of protein complexes.

Resolution levels — nested concentric zoom from cell population to single protein complex

Full description coming soon.